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- However, FH + subjects reported decreased stimulation during clamping, indicative of acute tolerance.
- Acute tolerance was shown to be controlled by changes in the BK channel's phosphorylation state.
- The reason this mechanism is not used for acute tolerance is because tolerance depends on the modified protein synthesis, which takes time.
- Cited advantages of clonazepam include a longer duration of action than diazepam and a lower propensity for the development of acute tolerance than lorazepam.
- Such aspects as the influence of body weight and sex on dosage requirements, the phenomenon of acute tolerance, the effects of renal and hepatic dysfunction and the importance of redistribution all led to publications.