deletion loopの例文
もっと例文: 1 2
- This dimer repairs longer insertion / deletion loops than MutS?.
- MSH3 typically forms the heterodimer MutS? with MSH2 in order to correct long insertion / deletion loops and base-base mispairs in microsatellites during DNA synthesis.
- MutS? can compensate somewhat for loss of base-base mispair correction functions, but is not suited for repairing many short, 1-2 base pair insertion / deletion loops.
- While both proteins have redundant function in base-base repairs, MutS? typically effects base-base mispair repairs and also performs repairs on the more common short inertion / deletion loops.
- Mutations causing MSH3 knockdown can lead to diminished capacity for cells to repair long insertion / deletion loops causing microsatellite instabilities ( MSI ) in the genome and allowing an increase in the rates of somatic mutation.