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  1. Balaban also developed new synthesis of oxazoles by azlactones, followed by dehidratation.
  2. The presence of oxazoles or thiazoles often indicates that the compound was synthesized in this fashion.
  3. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.
  4. It is used in the Van Leusen reaction which is used to convert aldehydes to nitriles or in the preparation of oxazoles and imidazoles.
  5. A popular extension of the Robinson-Gabriel cyclodehydration has been reported by Wipf " et al . " to allow the synthesis of substituated oxazoles from readily available amino acid derivatives.


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