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- Insulin induction of SREBP-1c is also involved in cholesterol metabolism.
- Inhibition of SREBP by betulin decreased the biosynthesis of cholesterol and fatty acid.
- SREBP-1c mediates MEF2C downregulation through a mechanism that remains to be determined.
- Growth factors affect expression of NFE2L1 through a mTORC and SREBP-1 mediated pathway.
- Its expression is induced by decreased sterol concentrations via sterol regulatory binding proteins ( SREBP ).