tafamidisの例文
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- Tafamidis is also approved for use in Brazil, Argentina, Mexico and Israel by the relevant authorities.
- Tafamidis is one such small molecule that has been approved by several international regulatory agencies for the treatment of Transthyretin Familial Amyloid Polyneuropathy.
- Recently the European Medicines Agency approved the use of Tafamidis or Vyndaqel ( a kinetic stabilizer of tetrameric transthyretin ) for the treatment of transthyretin amyloid diseases.
- Collectively, the tafamidis and diflunisal data provide compelling pharmacologic evidence supporting the amyloid hypothesis, the idea that active transthyretin aggregation causes the loss of post-mitotic tissue in this degenerative amyloid disease.
- Alternatively, a European Medicines Agency approved drug Tafamidis or Vyndaqel now exists which stabilizes transthyretin tetramers comprising wild type and different mutant subunits against amyloidogenesis halting the progression of peripheral neuropathy and autonomic nervous system dysfunction.