benznidazoleの例文

• Megazol in a study seems more active against Chagas than benznidazole but has not been studied in humans.
• Children aged six to 12 years with chronic disease have a cure rate of about 60 % with benznidazole.
• The drug is considerably more effective than standard benznidazole therapy ( for Chagas ) which is considered the gold standard.
• There are no vaccines to prevent these infections so drugs such as pentamidine and suramin, benznidazole and nifurtimox and used to treat infections.
• The paediatric dosage form of benznidazole is designed for infants and young children under 2 years of age ( 20 kg body weight ) infected congenitally.
• Mundo Sano and the Chemo pharmaceutical group developed a second generic version of benznidazole, which is manufactured by the Argentine company Laboratorio ELEA under the name Abarax.
• The paediatric dosage form of benznidazole was granted registration by Brazil ` s National Health Surveillance Agency ( ANVISA ) in 2011, and further endemic countries are targeted for obtaining registration.
• Benznidazole is the primary treatment of choice for Chagas disease, is produced in Latin America where the disease originates and is most prevalent, at the public pharma LAFEPE in Brasil.
• This mechanism has been well-established for 5-nitroimidazoles such as metronidazole, but it is unclear if the same mechanism can be expanded to 2-nitroimidazoles ( including benznidazole ).
• While the rate of cure declines the longer an adult has been infected with Chagas, treatment with benznidazole has been shown to slow the onset of heart disease in adults with chronic Chagas infections.
• However, some studies indicate treatment with benznidazole during the chronic phase, even if incapable of producing parasitologic cure, because it reduces electrocardiographic changes and a delays worsening of the clinical condition of the patient.
• Benznidazole has proven to be effective in the treatment of reactivated " T . cruzi " infections caused by immunosuppression, such as in people with AIDS or in those under immunosuppressive therapy related to organ transplants.