capzの例文

• When CapZ binds, it halts both of these processes.
• These molecules bind to CapZ itself to prevent it from binding to actin.
• CapZ works in concert with tropomodulin, which caps actin at pointed ends.
• A modest reduction in cardiac CapZ protein protects hearts against acute ischemia-reperfusion injury.
• Experimentation on chicken muscles have indicated that there are certain proteins that inhibit CapZ from binding.
• Competition for actin binding sites can also regulate CapZ binding, as seen with filament elongation factors.
• The primary sequence of CapZ-alpha2 contains three CapZ-alpha1 varies significantly among different tissues.
• The primary sequence of CapZ-alpha2 contains three CapZ-alpha1 varies significantly among different tissues.
• CapZ binds the barbed end of actin filaments and prevents addition or loss of actin monomers to filaments.
• CapZ is not regulated by calcium or calmodulin, as seen with other capping proteins, such as Gelsolin.
• CapZ also plays a role in cell movement ( cell crawling ) by controlling the lengths of the microfilaments.
• Findings of PKC? phosphorylation in animal models have been verified in humans; PKC? phosphorylates CapZ dynamics following cyclic strain.
• When CapZ is inhibited by regulating factors, microfilament polymerization or depolymerization occurs allowing lamellipodia and filopodia to grow out or retract.
• Examples of this type of protein are CapZ ( that binds the ( + ) ends depending on a cell s levels of Ca 2 + / calmodulin.
• Involves the degradation of polyphosphoinositides and reactivation of " barbed end " capping proteins Hsp70 and CapZ, thereby reinitiating barbed-end capping and greatly diminishing elongation.
• End-capping proteins such as CapZ prevent the addition or loss of monomers at the filament end where actin turnover is unfavorable, such as in the muscle apparatus.
• However, introduction of certain detergents ( in this case Triton X 100 ) prevent the binding of these molecules to CapZ; in turn allowing it to bind to the microfilament.
• The role of PKC? acting in non-mitochondrial regions of cardiomyocytes is less well understood, though some studies have identified CapZ may compete with PKC? for the binding of RACK2.
• In muscle, the interaction of CapZ with actin is critical during myofibrilogenesis, as administration of a CapZ monoclonal antibody or expression of CapZ mutant protein disrupts actin filament formation and assembly of myofibrils.
• In muscle, the interaction of CapZ with actin is critical during myofibrilogenesis, as administration of a CapZ monoclonal antibody or expression of CapZ mutant protein disrupts actin filament formation and assembly of myofibrils.