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michael acceptorの例文

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  • Also, what about the acid-catalysed hydration of Michael acceptors?
  • Can they act as Michael acceptors and / or electron-withdrawing groups?
  • The oxidation will lead to a benzoquinone like motif-- a Michael acceptor.
  • It is also a potent Michael acceptor.
  • Rauhut-Currier reaction is a reaction of activated alkene and a Michael acceptor, not an aldehyde or an imine.
  • My lecturer never addressed what happens to the Aldol EWGness of a deprotonated COO-group on a Michael acceptor, okay?
  • Additionally, the group cannot produce cross-reacting Michael acceptors that could act as alkylating agents towards nucleophilic species within cells.
  • I mean, if I'm frying in 200C hot oil, shouldn't I get a dehydration product ( a Michael acceptor ? ).
  • The enone moiety of " atrop "-abyssomicin C has a higher degree of the conjugation, which makes it a more active Michael acceptor.
  • Reaction with Michael acceptor "'48 "'under standard conditions yielded functionalized pyridine "'49 "'in 60 % overall yield.
  • As you probably know, Michael addition favours soft nucleophiles because Michael acceptors are soft electrophiles, dominated by HOMO-LUMO interactions more than electrostatic interactions  basic HSAB theory.
  • Note that pyrogallol is very nucleophilic enol-- ( an aromatic enol, but still an enol )-- so another pyrogallol molecule will then attack this Michael acceptor.
  • Additionally, Mannich bases can also be utilized as the Michael acceptor for the scheme, further diversifying the scope of starting materials that can be incorporated into the Kr鰄nke scheme.
  • With Michael acceptors the addition is also anti-Markovnikov because now a nucleophilic X  " reacts in a nucleophilic conjugate addition for example in the reaction of HCl with acrolein.
  • Irreversible inhibitors often contain reactive functional groups such as nitrogen mustards, aldehydes, haloalkanes, alkenes, Michael acceptors, DFP, right ), cysteine, threonine, or tyrosine.
  • This includes chemicals that : form irreversible bonds by electrophilic reaction; are metabolically activated by electrophiles; form Schiff bases with amino groups; and any type of a Michael acceptor.
  • In this example, the ?-carbon of the ?, ?-unsaturated ester "'1 "'formally acts as a nucleophile, whereas normally it would be expected to be a Michael acceptor.
  • I mean, a deprotonated COOH group is prolly not as electron-withdrawing as the protonated one, but I'm wondering if deprotonated acrylic acid is still a good Michael acceptor . talk ) 10 : 17, 12 January 2010 ( UTC)
  • TRPA1 is known to be activated by compounds capable of forming covalent chemical bonds with the protein's cysteins like isothiocyanates, which are the pungent chemicals in substances such as mustard oil and wasabi and Michael acceptors such as cinnamaldehyde in cinnamon, amongst numerous other substances.
  • Classical examples of the Michael reaction are the reaction between diethyl malonate ( Michael donor ) and diethyl fumarate ( Michael acceptor ), that of mesityl oxide and diethyl malonate, that of diethyl malonate and methyl crotonate, that of 2-nitropropane and methyl acrylate, that of " ethyl phenylcyanoacetate " and acrylonitrile and that of nitropropane and methyl vinyl ketone.