- Akt mediates suppression of Insig2a, a liver-specific transcript encoding the SREBP1c inhibitor INSIG2.
- LXR? autoregulates its own suppression via induction of SREBP1c which upregulates miRNA has-miR-613.
- Insulin, cholesterol derivatives, T3 and other endogenous molecules have been demonstrated to regulate the SREBP1c expression, particularly in rodents.
- Fructose-2, 6-bisphosphate ( ) also stimulates GK transcription, it seems by way of Akt2 rather than SREBP1c.